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Biomed Res Int. 2013;2013:984523. doi: 10.1155/2013/984523. Epub 2012 Dec 5.

Exercise training and work task induced metabolic and stress-related mRNA and protein responses in myalgic muscles.

Author information

  • 1Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, 5320 Odense M, Denmark. gsjogaard@health.sdu.dk

Abstract

The aim was to assess mRNA and/or protein levels of heat shock proteins, cytokines, growth regulating, and metabolic proteins in myalgic muscle at rest and in response to work tasks and prolonged exercise training. A randomized controlled trial included 28 females with trapezius myalgia and 16 healthy controls. Those with myalgia performed ~7 hrs repetitive stressful work and were subsequently randomized to 10 weeks of specific strength training, general fitness training, or reference intervention. Muscles biopsies were taken from the trapezius muscle at baseline, after work and after 10 weeks intervention. The main findings are that the capacity of carbohydrate oxidation was reduced in myalgic compared with healthy muscle. Repetitive stressful work increased mRNA content for heat shock proteins and decreased levels of key regulators for growth and oxidative metabolism. In contrast, prolonged general fitness as well as specific strength training decreased mRNA content of heat shock protein while the capacity of carbohydrate oxidation was increased only after specific strength training.

PMID:
23509827
[PubMed - indexed for MEDLINE]
PMCID:
PMC3591204
Free PMC Article
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