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Cell J. 2011 Fall;13(3):131-6. Epub 2011 Sep 23.

Neoplastic bone marrow niche: hematopoietic and mesenchymal stem cells.

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  • 11. Department of Hematology and Blood Banking School of Medical Sciences, Tarbiat Modares University, Tehran, Iran ; 2. Research Center of Thalassemia and Hemoglobinopathy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.


The neoplastic niche comprises complex interactions between multiple cell types and molecules requiring cell-cell signaling as well as local secretion. These niches are important for both the maintenance of cancer stem cells and the induction of neoplastic cells survival and proliferation. Each niche contains a population of tumor stem cells supported by a closely associated vascular bed comprising mesenchyme-derived cells and extracellular matrix. Targeting cancer stem cells and neoplastic niche may provide new therapies to eradicate tumors. Much progress has been very recently made in the understanding of the cellular and molecular interactions in the microenvironment of neoplastic niches. This review article provides an overview of the neoplastic niches in the bone marrow. In addition to highlighting recent advances in the field, we will also discuss components of the niche and their signaling pathways.


Bone Marrow; Cancer; Neoplastic Niche; Stem Cells

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