Abstract
Multidrug-resistant (MDR) Acinetobacter baumannii is a worldwide concern as cause of serious nosocomial infections. We analysed 140 non-duplicate Acinetobacter sp. isolates from hospitalised patients in a tertiary care centre; 87% were MDR and 20% (28/140) meropenem resistant. Metallo-β-lactamase was produced by 16 of these, detected by ethylene-diamine-tetra-acetic acid disc synergy test. AmpC β-lactamase and efflux pump were present in 17 and 4 of the meropenem-resistant Acinetobacter, respectively. 9/16 MBL-positive isolates carried genes for carbapenem resistance as shown by polymerase chain reaction.
MeSH terms
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Acinetobacter Infections / epidemiology*
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Acinetobacter Infections / microbiology*
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Acinetobacter baumannii / drug effects*
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Acinetobacter baumannii / isolation & purification
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Anti-Bacterial Agents / pharmacology*
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Carbapenems / pharmacology*
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Child
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Child, Preschool
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Cross Infection / epidemiology*
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Cross Infection / microbiology*
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Female
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Humans
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India / epidemiology
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Infant
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Infant, Newborn
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Male
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Microbial Sensitivity Tests
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Middle Aged
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Polymerase Chain Reaction
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Prospective Studies
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Tertiary Healthcare
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Young Adult
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beta-Lactam Resistance
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beta-Lactamases / genetics
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beta-Lactamases / metabolism
Substances
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Anti-Bacterial Agents
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Carbapenems
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beta-Lactamases