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Neurosci Lett. 2013 May 10;542:26-9. doi: 10.1016/j.neulet.2013.02.052. Epub 2013 Mar 15.

Whole-brain functional connectivity increases with extended duration of focal epileptiform activity.

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  • 1Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198-2045, USA. deepak.madhavan@unmc.edu

Abstract

The analysis of interictal epileptiform discharges (IEDs) using magnetoencephalography (MEG) is utilized for the localization of seizure onset zones in the presurgical planning of epilepsy patients. Additionally, resting-state functional connectivity analyses using the IED area may provide novel insight into the underlying brain networks. In this study, we evaluate whether chronicity of seizures is related to whole-brain functional connectivity metrics using the area of IED generation (derived from MEG) as the seed region. We found a positive correlation between the duration of seizures and beta-band functional connectivity between the epileptogenic zone and other brain areas. This suggests the presence of inhibitory GABAergic modulation of distal brain regions in response to chronic epileptiform activity.

Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

PMID:
23506687
[PubMed - indexed for MEDLINE]
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