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Clin Lab. 2013;59(1-2):177-83.

Usefulness of procalcitonin for severity assessment in patients with acute cholangitis.

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  • 1Department of Gastroenterology and Hepatology, Ohme Municipal General Hospital, 4-16-5 Higashiohme, Ohme-shi, Tokyo 198-0042, Japan.



The aim of the present study was to examine the usability of procalcitonin (PCT) for severity assessment in patients with acute cholangitis (AC).


Serum PCT concentrations were measured on admission in patients with AC. Patients were classified with mild, moderate, or severe AC based on severity assessment guidelines.


We included 159 treatment-naïve patients with AC (95 males, 64 females) in this study. The median PCT concentrations were 0.08 ng/mL (interquartile range (IQR) 0.04 - 0.18 ng/mL), 0.37 ng/mL (IQR 0.15 - 1.85 ng/mL), and 5.56 ng/mL (IQR 3.59 - 25.89 ng/mL) in patients with mild, moderate and severe AC, respectively. PCT concentrations were significantly higher in patients with severe AC than in patients with moderate AC (p < 0.0001), and in patients with moderate AC than in patients with mild AC (p < 0.0001). The areas under the receiver operating characteristic curves for PCT to discriminate patients with moderate and severe AC were 0.84 (95% CI 0.77 to 0.92, p < 0.001) and 0.86 (95% CI 0.78 to 0.92, p < 0.001), respectively.


Serum PCT concentrations were elevated in patients with AC and may be a useful parameter for the severity assessment of AC.

[PubMed - indexed for MEDLINE]
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