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Clin Lab. 2013;59(1-2):177-83.

Usefulness of procalcitonin for severity assessment in patients with acute cholangitis.

Author information

  • 1Department of Gastroenterology and Hepatology, Ohme Municipal General Hospital, 4-16-5 Higashiohme, Ohme-shi, Tokyo 198-0042, Japan. hamano-k@mghp.ome.tokyo.jp

Abstract

BACKGROUND:

The aim of the present study was to examine the usability of procalcitonin (PCT) for severity assessment in patients with acute cholangitis (AC).

METHODS:

Serum PCT concentrations were measured on admission in patients with AC. Patients were classified with mild, moderate, or severe AC based on severity assessment guidelines.

RESULTS:

We included 159 treatment-naïve patients with AC (95 males, 64 females) in this study. The median PCT concentrations were 0.08 ng/mL (interquartile range (IQR) 0.04 - 0.18 ng/mL), 0.37 ng/mL (IQR 0.15 - 1.85 ng/mL), and 5.56 ng/mL (IQR 3.59 - 25.89 ng/mL) in patients with mild, moderate and severe AC, respectively. PCT concentrations were significantly higher in patients with severe AC than in patients with moderate AC (p < 0.0001), and in patients with moderate AC than in patients with mild AC (p < 0.0001). The areas under the receiver operating characteristic curves for PCT to discriminate patients with moderate and severe AC were 0.84 (95% CI 0.77 to 0.92, p < 0.001) and 0.86 (95% CI 0.78 to 0.92, p < 0.001), respectively.

CONCLUSIONS:

Serum PCT concentrations were elevated in patients with AC and may be a useful parameter for the severity assessment of AC.

PMID:
23505924
[PubMed - indexed for MEDLINE]
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