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PLoS One. 2013;8(3):e58408. doi: 10.1371/journal.pone.0058408. Epub 2013 Mar 7.

MEG source localization using invariance of noise space.

Author information

  • 1Key Laboratory for NeuroInformation of Ministry of Education, University of Electronic Science and Technology of China, Chengdu, China.

Abstract

We propose INvariance of Noise (INN) space as a novel method for source localization of magnetoencephalography (MEG) data. The method is based on the fact that modulations of source strengths across time change the energy in signal subspace but leave the noise subspace invariant. We compare INN with classical MUSIC, RAP-MUSIC, and beamformer approaches using simulated data while varying signal-to-noise ratios as well as distance and temporal correlation between two sources. We also demonstrate the utility of INN with actual auditory evoked MEG responses in eight subjects. In all cases, INN performed well, especially when the sources were closely spaced, highly correlated, or one source was considerably stronger than the other.

PMID:
23505502
[PubMed - indexed for MEDLINE]
PMCID:
PMC3591341
Free PMC Article

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