Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Indian Pediatr. 2013 Jul;50(7):649-53. Epub 2012 Dec 5.

Comparison of analgesic effect of direct breastfeeding, oral 25% dextrose solution and placebo during 1st DPT vaccination in healthy term infants: a randomized, placebo controlled trial.

Author information

  • 1Departments of Pediatrics, LLRM, Medical College, Meerut, UP, and *Government Medical College, Chandigarh, India.

Abstract

OBJECTIVE:

To compare analgesic effect of direct breast feeding, 25% dextrose solution and placebo as we give 1st intramuscular whole cell DPT injection to 6week - 3month old infants.

DESIGN:

Randomized, placebo controlled trial.

SETTINGS:

Immunization clinic of Department of Pediatrics, LLRM Medical College.

PARTICIPANTS:

Infants coming for their 1st DPT vaccination were randomized in to three groups of 40 each.

MAIN OUTCOME MEASURES:

OUTCOME MEASURES:

The primary outcome variable was the duration of cry after vaccination. Secondary outcome variables were Modified Facial Coding Score (MFCS) and latency of onset of cry.

RESULTS:

120 babies were equally enrolled in breast feed group, 25% dextrose fed group and distilled water fed group. Median (interquartile range) of duration of cry was significantly lower in breast fed (33.5 (17-54) seconds) and 25% dextrose fed babies (47.5 (31-67.5) seconds) as compared to babies given distilled water (80.5 (33.5-119.5) seconds) (P<0.001). MFCS at 1 min and 3 min was significantly lower in direct breast fed and dextrose fed babies.

CONCLUSION:

Direct breastfeeding and 25% dextrose act as analgesic in young infants undergoing DPT vaccination in young infants less than 3 month of age.

Comment in

PMID:
23502661
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Indian Pediatrics
    Loading ...
    Write to the Help Desk