Isolation and identification of a new anti-inflammatory cyathane diterpenoid from the medicinal fungus Cyathus hookeri Berk

Zhenyu Xu; Sha Yan; Kaishun Bi; Junjie Han; Yuhui Chen; Zhiang Wu; Yuhui Chen; Hongwei Liu

doi:10.1016/j.fitote.2013.03.002

Isolation and identification of a new anti-inflammatory cyathane diterpenoid from the medicinal fungus Cyathus hookeri Berk

Fitoterapia. 2013 Apr:86:159-62. doi: 10.1016/j.fitote.2013.03.002. Epub 2013 Mar 14.

Authors

Zhenyu Xu¹, Sha Yan, Kaishun Bi, Junjie Han, Yuhui Chen, Zhiang Wu, Yuhui Chen, Hongwei Liu

Affiliation

¹ School of Business Administration, Shenyang Pharmaceutical University, Shenyang 110016, PR China.

PMID: 23500388
DOI: 10.1016/j.fitote.2013.03.002

Abstract

A new cyathane diterpene, named as cyathin I (1), as well as two known cyathane diterpenes (12R)-11a,14a-epoxy-13a,14b,15-trihydroxycyath-3-ene (2) and erinacine I (3), were isolated from the liquid culture of Cyathus hookeri Berk. Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 1-3 showed inhibition against nitric oxide production in macrophages with an IC50 value of 15.5, 52.3, and 16.8 μM, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Inflammatory Agents / isolation & purification
Anti-Inflammatory Agents / pharmacology*
Biological Products / chemistry
Biological Products / pharmacology*
Cyathus / chemistry*
Diterpenes / isolation & purification
Diterpenes / pharmacology*
Inflammation / metabolism*
Inhibitory Concentration 50
Macrophages / drug effects*
Macrophages / metabolism
Mice
Nitric Oxide / biosynthesis*

Substances

Anti-Inflammatory Agents
Biological Products
Diterpenes
cyathane
cyathin I
erinacine I
Nitric Oxide