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Biosens Bioelectron. 2013 Jul 15;45:281-6. doi: 10.1016/j.bios.2013.01.021. Epub 2013 Jan 18.

High-performance cholesterol sensor based on the solution-gated field effect transistor fabricated with ZnO nanorods.

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  • 1Department of BIN Fusion Technology, School of Semiconductor and Chemical Engineering, Chonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju 561-756, Republic of Korea.

Abstract

A high-performance cholesterol sensor based on solution-gated field-effect-transistor (FET) was fabricated by using the vertically aligned ZnO nanorods (ZnO NRs) grown selectively on pre-patterned substrate in solution. The structural characterization showed that the as-grown ZnO NRs are vertically aligned, high purity single crystalline. The active layer of ZnO NRs between source and drain electrodes was immobilized with cholesterol oxidase (ChOx) enzyme. The performance of the fabricated FET sensor has been examined with the cholesterol solutions with and without electroactive species, the human serum (H4522), and the freshly drawn blood sample. The FET sensor provided a real-time response towards a wide range of cholesterol concentration (0.001-45 mM) with high sensitivity (10 μA cm(-2) mM(-1)) and selectivity.

Copyright © 2013 Elsevier B.V. All rights reserved.

PMID:
23500376
[PubMed - indexed for MEDLINE]
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