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Cell. 2013 Mar 14;152(6):1298-307. doi: 10.1016/j.cell.2013.02.012.

Long noncoding RNAs: cellular address codes in development and disease.

Author information

  • 1Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

In biology as in real estate, location is a cardinal organizational principle that dictates the accessibility and flow of informational traffic. An essential question in nuclear organization is the nature of the address code--how objects are placed and later searched for and retrieved. Long noncoding RNAs (lncRNAs) have emerged as key components of the address code, allowing protein complexes, genes, and chromosomes to be trafficked to appropriate locations and subject to proper activation and deactivation. lncRNA-based mechanisms control cell fates during development, and their dysregulation underlies some human disorders caused by chromosomal deletions and translocations.

Copyright © 2013 Elsevier Inc. All rights reserved.

PMID:
23498938
[PubMed - indexed for MEDLINE]
PMCID:
PMC3651923
Free PMC Article

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