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Cell. 2013 Mar 14;152(6):1252-69. doi: 10.1016/j.cell.2013.02.034.

Dynamic integration of splicing within gene regulatory pathways.

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  • 1Banting and Best Department of Medical Research, Donnelly Centre, University of Toronto, Toronto, ON M5S 1A8, Canada.


Precursor mRNA splicing is one of the most highly regulated processes in metazoan species. In addition to generating vast repertoires of RNAs and proteins, splicing has a profound impact on other gene regulatory layers, including mRNA transcription, turnover, transport, and translation. Conversely, factors regulating chromatin and transcription complexes impact the splicing process. This extensive crosstalk between gene regulatory layers takes advantage of dynamic spatial, physical, and temporal organizational properties of the cell nucleus, and further emphasizes the importance of developing a multidimensional understanding of splicing control.

Copyright © 2013 Elsevier Inc. All rights reserved.

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