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Expert Opin Med Diagn. 2008 Jul;2(7):813-28. doi: 10.1517/17530059.2.7.813.

Chip-based molecular diagnostics using metal nanoparticles.

Author information

  • 1Institute of Photonic Technology, POB 100239, 07702 Jena, Germany +49 3641 206304 ; +49 3641 206344 ; fritzsche@ipht-jena.de.

Abstract

BACKGROUND:

Chip-based bioanalytical methods represent a promising approach for a highly parallel and robust analysis with minimal sample volumes. Key process parameters that can be decisive for certain applications are determined by the detection scheme utilized.

OBJECTIVE:

This review addresses typical requirements of chip-based detection systems, especially for the emerging field of point-of-care diagnostics that make possible field detection with less-trained personnel, robust assays as well as low instrumentation costs.

METHODS:

The use of metal nanoparticles as labels represents a promising approach. They exhibit a high stability in signal and new detection schemes that would allow for robustness and low-cost readout.

RESULTS/CONCLUSION:

First examples of this kind have been established and are in the market, and more are in the development pipeline.

PMID:
23495820
[PubMed]
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