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J Tissue Eng Regen Med. 2015 Mar;9(3):315-8. doi: 10.1002/term.1688. Epub 2013 Mar 12.

PEG hydrogel degradation and the role of the surrounding tissue environment.

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  • 1Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.


Poly(ethylene glycol) (PEG)-based hydrogels are extensively used in a variety of biomedical applications, due to ease of synthesis and tissue-like properties. Recently there have been varied reports regarding PEG hydrogel's degradation kinetics and in vivo host response. In particular, these studies suggest that the surrounding tissue environment could play a critical role in defining the inflammatory response and degradation kinetics of PEG implants. In the present study we demonstrated a potential mechanism of PEG hydrogel degradation, and in addition we show potential evidence of the role of the surrounding tissue environment on producing variable inflammatory responses.

Copyright © 2013 John Wiley & Sons, Ltd.


degradation; hydrogel; inflammatory response; macrophages; neutrophils; poly(ethylene glycol); reactive oxygen species (ROS)

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