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Bioorg Med Chem Lett. 2013 Apr 15;23(8):2336-9. doi: 10.1016/j.bmcl.2013.02.061. Epub 2013 Feb 24.

Cytotoxic scalarane sesterterpenes from a Korean marine sponge Psammocinia sp.

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  • 1Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, 151-747 Seoul, Republic of Korea.

Abstract

Three novel scalarane sesterterpenes were isolated from a Korean marine sponge, Psammocinia sp., along with four known derivatives. Their structures were elucidated on the basis of NMR, MS and IR spectroscopic data. The three new compounds are 12-deacetoxy-23-hydroxyscalaradial (1), 12-dehydroxy-23-hydroxyhyrtiolide (2) and 12-O-acetyl-16-deacetoxy-23-acetoxyscalarafuran (3), respectively, and the four known compounds are 12-deacetoxy-23-hydroxyheteronemin (4), 12-deacetoxy-23-acetoxy-19-O-acetylscalarin (5), 12-deacetoxy-23-O-acetoxyheteronemin (6) and 12-deacetoxyscalaradial (7). They exhibited cytotoxicity against intractable human cancer cell lines A498, ACHN, MIA-paca and PANC-1, with an IC50 range of 0.4-48 μM.

Copyright © 2013 Elsevier Ltd. All rights reserved.

PMID:
23489626
[PubMed - indexed for MEDLINE]
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