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PLoS One. 2013;8(3):e57707. doi: 10.1371/journal.pone.0057707. Epub 2013 Mar 6.

Identifying correlations between chromosomal proximity of genes and distance of their products in protein-protein interaction networks of yeast.

Author information

  • 1Institute for System Analysis and Computer Science Antonio Ruberti, National Research Council of Italy, Rome, Italy. daniele.santoni@iasi.cnr.it

Abstract

In this article we present evidence for a relationship between chromosome gene loci and the topological properties of the protein-protein interaction network corresponding to the set of genes under consideration. Specifically, for each chromosome of the Saccharomyces cerevisiae genome, the distribution of the intra-chromosome inter-gene distances was analyzed and a positive correlation with the distance among the corresponding proteins of the protein-protein interaction network was found. In order to study this relationship we used concepts based on non-parametric statistics and information theory. We provide statistical evidence that if two genes are closely located, then it is likely that their protein products are closely located in the protein-protein interaction network, or in other words, that they are involved in the same biological process.

PMID:
23483922
[PubMed - indexed for MEDLINE]
PMCID:
PMC3590303
Free PMC Article

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