Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
PLoS One. 2013;8(3):e57707. doi: 10.1371/journal.pone.0057707. Epub 2013 Mar 6.

Identifying correlations between chromosomal proximity of genes and distance of their products in protein-protein interaction networks of yeast.

Author information

  • 1Institute for System Analysis and Computer Science Antonio Ruberti, National Research Council of Italy, Rome, Italy. daniele.santoni@iasi.cnr.it


In this article we present evidence for a relationship between chromosome gene loci and the topological properties of the protein-protein interaction network corresponding to the set of genes under consideration. Specifically, for each chromosome of the Saccharomyces cerevisiae genome, the distribution of the intra-chromosome inter-gene distances was analyzed and a positive correlation with the distance among the corresponding proteins of the protein-protein interaction network was found. In order to study this relationship we used concepts based on non-parametric statistics and information theory. We provide statistical evidence that if two genes are closely located, then it is likely that their protein products are closely located in the protein-protein interaction network, or in other words, that they are involved in the same biological process.

[PubMed - indexed for MEDLINE]
Free PMC Article

Images from this publication.See all images (8)Free text

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Public Library of Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk