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Oncoimmunology. 2013 Jan 1;2(1):e22338.

Plasmacytoid dendritic cells deficient in IFNα production promote the amplification of FOXP3+ regulatory T cells and are associated with poor prognosis in breast cancer patients.

Author information

  • 1Université de Lyon; Lyon, France ; Université Lyon 1; ISPB; Lyon, France ; INSERM U1052; Centre de Recherche en Cancérologie de Lyon; Lyon, France ; CNRS UMR5286; Centre de Recherche en Cancérologie de Lyon; Lyon, France ; LabEx DEVweCAN; Lyon, France ; Centre Léon Bérard; Lyon, France.

Abstract

The accumulation of plasmacytoid dendritic cells (pDCs) within breast carcinoma lesions is associated with a poor clinical outcome. We demonstrated that the deleterious impact of tumor-associated pDCs (TApDCs) is due to their impaired capacity to produce Type I interferon, which in turn potentiates their ability to sustain the proliferation of immunosuppressive regulatory T cells.

KEYWORDS:

breast cancer; immunosuppression; plasmacytoid dendritic cells; regulatory T cells; tolerance

PMID:
23482834
[PubMed]
PMCID:
PMC3583914
Free PMC Article
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