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Fish Physiol Biochem. 2013 Aug;39(4):1031-41. doi: 10.1007/s10695-012-9760-8. Epub 2013 Mar 9.

Ameliorating effect of β-carotene on antioxidant response and hematological parameters of mercuric chloride toxicity in Nile tilapia (Oreochromis niloticus).

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  • 1Department of Physiology, College of Veterinary Medicine, Mansoura University, El-Gomheria Street, Mansoura, Egypt.


The impact of different levels of dietary β-carotene to alleviate the effect of mercuric chloride toxicity in Nile tilapia was assessed. Semi-purified diets containing 0, 40, and 100 mg β-carotene kg(-1) dry diet were fed for 21 days, which were subjected to sublethal concentration of mercuric chloride (0.05 ppm). Hematological and biochemical parameters, lipid profile, and antioxidant response were examined. All hematological parameters of tilapia fish starting from second week of toxicity were significantly decreased. A significant increasing trend in liver enzymes (ALT and AST) were observed parallel to the time of toxicity and peroxide radicals (MDA) appearing significantly increased in toxicated group without carotene supplement, although carotene supplementation return all parameters within the control levels. Mercury accumulated significantly in fish liver and white muscles in toxicated group while it showed a significant reduction in dietary β-carotene-treated group. Overall, it can be used as immunostimulant and alleviate the suppression effect resulted from immune depressive stressful condition in farmed Nile tilapia.

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