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J Nephrol. 2013 Nov-Dec;26(6):1170-8. doi: 10.5301/jn.5000252. Epub 2013 Mar 6.

Role of human leukocyte antigen-G 14-base pair polymorphism in kidney transplantation outcomes.

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  • 1Regional Government Reference Center for Organ, Tissue and Cell Transplantation, R. Binaghi Hospital - ASL 8, Cagliari - Italy.

Abstract

BACKGROUND:

Both the membrane-bound and soluble forms of human leukocyte antigen-G (HLA-G) molecules exhibit a multitude of immunomodulatory properties that can potentially obviate or delay graft rejection. The 14-base pair (14-bp) polymorphism in the 3'-untranslated region of the HLA-G gene is thought to have a role in soluble HLA-G (sHLA-G) expression.

METHODS:

In this study, we retrospectively investigated a large cohort of 418 kidney transplant recipients with the aim of establishing whether the HLA-G 14-bp insertion/deletion polymorphism could serve as an effective genetic risk marker for acute and/or chronic deterioration of transplanted kidney function.

RESULTS:

A statistically significant higher incidence of chronic kidney dysfunction leading to allograft loss was observed in transplant recipients homozygous for the HLA-G 14-bp deletion polymorphism. This difference increased over time and was confirmed by progressive decline in the glomerular filtration rate.

CONCLUSIONS:

These results suggest that alongside other factors previously consolidated in clinical practice, recipient HLA-G 14-bp genotype may serve as an adjuvant independent predictor of long-term outcome of kidney transplantation.

PMID:
23475463
[PubMed - in process]
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