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Cell Metab. 2013 Mar 5;17(3):329-41. doi: 10.1016/j.cmet.2013.02.007.

Iron and diabetes risk.

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  • 1Departments of Medicine and Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.

Abstract

Iron overload is a risk factor for diabetes. The link between iron and diabetes was first recognized in pathologic conditions-hereditary hemochromatosis and thalassemia-but high levels of dietary iron also impart diabetes risk. Iron plays a direct and causal role in diabetes pathogenesis mediated both by β cell failure and insulin resistance. Iron also regulates metabolism in most tissues involved in fuel homeostasis, with the adipocyte in particular serving an iron-sensing role. The underlying molecular mechanisms mediating these effects are numerous and incompletely understood but include oxidant stress and modulation of adipokines and intracellular signal transduction pathways.

Copyright © 2013 Elsevier Inc. All rights reserved.

PMID:
23473030
[PubMed - indexed for MEDLINE]
PMCID:
PMC3648340
Free PMC Article

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