Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Pest Manag Sci. 2013 May;69(5):559-63. doi: 10.1002/ps.3479. Epub 2013 Mar 7.

In search of new herbicidal inhibitors of the non-mevalonate pathway.

Author information

  • 1BASF-SE, GVA/HC-B009, Global Research Herbicides, Ludwigshafen, Germany. matthias.witschel@basf.com


The first five steps of the non-mevalonate pathway have been tested in high-throughput screening (HTS) campaigns, using enzymes of plant origin. Hit rates were in general relatively low, which could be attributed to the high polarity and charged nature of substrates and active sites of these enzymes. Still, for all the enzymes, apart from IspF (2-methylerythritol 2,4-cyclodiphosphate synthase), inhibitors could be identified with activities below 100 μM, and these were followed up to identify structure-activity relationships (SARs). For the enzyme IspD (2C-methyl-D-erythritol 4-phosphate cytidyltransferase), inhibitors with IC50 down to 35 nM were identified that also showed herbicidal activity.

© 2013 Society of Chemical Industry.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for John Wiley & Sons, Inc.
    Loading ...
    Write to the Help Desk