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Chem Commun (Camb). 2013 Apr 18;49(30):3107-9. doi: 10.1039/c3cc39272d. Epub 2013 Mar 8.

DNA-templated Ag nanoclusters as signal transducers for a label-free and resettable keypad lock.

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  • 1State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, People's Republic of China.


We present a unique, label-free and resettable molecular keypad lock that utilizes DNA-modulated Ag nanoclusters (Ag NCs) as signal responsers. The present work demonstrates the first example that exonuclease-catalyzed DNA hydrolysis reaction could be used to achieve the RESET function of a molecular keypad without complicated procedures.

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