Development of CD27+ marginal zone B cells requires GALT

Eur J Immunol. 2013 Jun;43(6):1484-8. doi: 10.1002/eji.201243205. Epub 2013 Apr 19.

Abstract

In species other than mouse, little is known about the origin and development of marginal zone (MZ) B cells. Using cross-reactive antibodies, we identified and characterized splenic MZ B cells in rabbits as CD27(+) CD23(-). In rabbits in which organized gut-associated lymphoid tissue (GALT) was surgically removed at birth, we found only CD23(+) follicular (FO) B cells and almost no CD27(+) MZ B cells in the spleen, indicating that GALT is required for the development of splenic MZ B cells. These findings lead us to suggest that commensal microbiota contribute to the development of MZ B cells.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Animals, Newborn
  • B-Lymphocytes / immunology*
  • Cell Differentiation
  • Intestines / immunology*
  • Lymphoid Tissue / surgery
  • Metagenome / immunology
  • Mice
  • Rabbits
  • Receptors, IgE / metabolism
  • Spleen / immunology*
  • Tumor Necrosis Factor Receptor Superfamily, Member 7 / metabolism

Substances

  • Receptors, IgE
  • Tumor Necrosis Factor Receptor Superfamily, Member 7