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Dev Biol. 2013 May 15;377(2):375-84. doi: 10.1016/j.ydbio.2013.02.019. Epub 2013 Mar 4.

Dlg5 maintains apical aPKC and regulates progenitor differentiation during lung morphogenesis.

Author information

  • 1Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, C3-168, Seattle, WA 98109, USA. nechipot@ohsu.edu

Abstract

Cell polarity plays an important role in tissue morphogenesis; however, the mechanisms of polarity and their role in mammalian development are still poorly understood. We show here that membrane-associated guanylate kinase protein Dlg5 is required for proper branching morphogenesis and progenitor differentiation in mammalian lung. We found that during lung development Dlg5 functions as an apical-basal polarity protein, which is necessary for the apical maintenance of atypical protein kinase C (aPKC). These results identify Dlg5 as a regulator of apical polarity complexes and uncover the critical function of Dlg5 in branching morphogenesis and differentiation of lung progenitor cells.

Copyright © 2013 Elsevier Inc. All rights reserved.

PMID:
23466739
[PubMed - indexed for MEDLINE]
PMCID:
PMC3652546
Free PMC Article
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