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Bioorg Med Chem Lett. 2013 Apr 1;23(7):2069-73. doi: 10.1016/j.bmcl.2013.01.127. Epub 2013 Feb 9.

Anti-adipogenic diarylheptanoids from Alnus hirsuta f. sibirica on 3T3-L1 cells.

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  • 1College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Daehak-Dong, San 56-1, Sillim-Dong, Gwanak-Gu, Seoul 151-742, Republic of Korea.

Abstract

A new diarylheptanoid, (5S)-hydroxy-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)-hepta-1E-en-3-one (1), was isolated along with seventeen known diarylheptanoids (2-18) from the methanol extract of Alnus hirsuta f. sibirica leaves using bioactivity-guided fractionation. Among the isolated compounds, compounds 1 and 2 and 4-12 reduced lipid accumulation dose-dependently in 3T3-L1 preadipocytes. Of the compounds active in the present assay system, the most potent compound 7, platyphyllonol-5-O-β-d-xylopyranoside, significantly suppressed the induction of peroxisome proliferator activated receptor γ (PPARγ and CCAAT/enhancer binding protein α (C/EBPα) protein expression, and inhibited adipocyte differentiation induced by troglitazone, a PPARγ agonist. It was demonstrated that compound 7 has anti-adipogenic activity mediated by the regulation of PPARγ dependent pathways.

Copyright © 2013 Elsevier Ltd. All rights reserved.

PMID:
23465614
[PubMed - indexed for MEDLINE]
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