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Am J Gastroenterol. 2013 May;108(5):811-7. doi: 10.1038/ajg.2013.47. Epub 2013 Mar 5.

A randomized controlled trial of an online intervention to improve gluten-free diet adherence in celiac disease.

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  • 1Clinical Psychology Unit, The University of Sydney, Sydney, New South Wales, Australia.



To test the effectiveness of an interactive online intervention to improve gluten free diet adherence in adults with celiac disease.


A Randomized controlled trial was conducted. A total of 189 adults with biopsy-confirmed celiac disease were recruited and randomized to receive the intervention (n=101) or to a waitlist control condition (n=88). Post-intervention data was available for 70 intervention and 64 waitlist participants. Three month follow-up data was obtained for 46/50 completers from the intervention group. The primary outcome measure was gluten-free diet adherence. Secondary outcomes were gluten-free diet knowledge, quality of life and psychological symptoms.


Results were based on intention-to-treat analyses. The intervention group evidenced significantly improved gluten-free diet adherence, and gluten-free diet knowledge following the treatment period relative to the waitlist control group. The change in knowledge did not contribute to the change in adherence. These improvements were maintained at 3-month' follow-up.


The online program was effective in improving adherence and represents a promising resource for individuals with celiac disease who are struggling to achieve or maintain adequate gluten free diet adherence.

[PubMed - indexed for MEDLINE]
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