J Ethnopharmacol. 1990 Apr;29(1):51-7.

Preliminary evaluation of extracts of Alstonia scholaris bark for in vivo antimalarial activity in mice.

Source

Department of Experimental Medicine, Postgraduate Institute of Medicinal Education and Research, Chandigarh, India.

Abstract

The petroleum either extract and methanol extract of the bark of Alstonia scholaris were found to be devoid of antiamalarial activity in mice infected with Plasmodium berghei. However, a dose-dependent improvement of conditions and delayed mortality amongst animals receiving methanol extract of A. scholaris was noticed. Studies with A. constricta and alstonine shall help resolve the antimalarial status of the bark in question.

PMID:: 2345460; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Elsevier Science

Medical

Malaria - MedlinePlus Health Information

Supplemental Content

Related citations

In vivo antimalarial activity of Vernonia amygdalina. [Br J Biomed Sci. 2003]
In vivo antimalarial activity of Vernonia amygdalina.
Abosi AO, Raseroka BH. Br J Biomed Sci. 2003; 60(2):89-91.
The evaluation of the acute toxicity and long term safety of hydroalcoholic extract of Sapthaparna (Alstonia scholaris) in mice and rats. [Toxicol Lett. 2004]
The evaluation of the acute toxicity and long term safety of hydroalcoholic extract of Sapthaparna (Alstonia scholaris) in mice and rats.
Baliga MS, Jagetia GC, Ulloor JN, Baliga MP, Venkatesh P, Reddy R, Rao KV, Baliga BS, Devi S, Raju SK, et al. Toxicol Lett. 2004 Jul 15; 151(2):317-26.
Potential of a Khaya ivorensis -Alstonia boonei extract combination as antimalarial prophylactic remedy. [J Ethnopharmacol. 2011]
Potential of a Khaya ivorensis -Alstonia boonei extract combination as antimalarial prophylactic remedy.
Tepongning RN, Lucantoni L, Nasuti CC, Dori GU, Yerbanga SR, Lupidi G, Marini C, Rossi G, Esposito F, Habluetzel A. J Ethnopharmacol. 2011 Sep 1; 137(1):743-51. Epub 2011 Jun 30.
Antimalarial activities and toxicities of three plants used as traditional remedies for malaria in the Democratic Republic of Congo: Croton mubango , Nauclea pobeguinii and Pyrenacantha staudtii. [Ann Trop Med Parasitol. 2005]
Antimalarial activities and toxicities of three plants used as traditional remedies for malaria in the Democratic Republic of Congo: Croton mubango , Nauclea pobeguinii and Pyrenacantha staudtii.
Mesia GK, Tona GL, Penge O, Lusakibanza M, Nanga TM, Cimanga RK, Apers S, Van Miert S, Totte J, Pieters L, et al. Ann Trop Med Parasitol. 2005 Jun; 99(4):345-57.
Review Alstonia scholaris Linn R Br in the treatment and prevention of cancer: past, present, and future. [Integr Cancer Ther. 2010]
Review Alstonia scholaris Linn R Br in the treatment and prevention of cancer: past, present, and future.
Manjeshwar Shrinath Baliga. Integr Cancer Ther. 2010 Sep; 9(3):261-9. Epub 2010 Aug 11.

See reviews... See all...

Cited by 1 PubMed Central article

The alkaloid alstonine: a review of its pharmacological properties. [Evid Based Complement Alternat Med. 2006]
The alkaloid alstonine: a review of its pharmacological properties.
Elisabetsky E, Costa-Campos L. Evid Based Complement Alternat Med. 2006 Mar; 3(1):39-48. Epub 2006 Jan 16.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Preliminary evaluation of extracts of Alstonia scholaris bark for in vivo antima...
Preliminary evaluation of extracts of Alstonia scholaris bark for in vivo antimalarial activity in mice.
J Ethnopharmacol. 1990 Apr ;29(1):51-7.

PubMed
Stress-associated reductions of cytotoxic T lymphocytes and natural killer cells...
Stress-associated reductions of cytotoxic T lymphocytes and natural killer cells in asymptomatic HIV infection.
Am J Psychiatry. 1995 Apr ;152(4):543-50.

PubMed
Human immunodeficiency virus (HIV)-specific cytotoxic T lymphocyte activity in H...
Human immunodeficiency virus (HIV)-specific cytotoxic T lymphocyte activity in HIV-exposed seronegative persons.
J Infect Dis. 1999 Mar ;179(3):538-47.

PubMed
Factors affecting the success of human blastocyst development and pregnancy foll...
Factors affecting the success of human blastocyst development and pregnancy following in vitro fertilization and embryo transfer.
Fertil Steril. 1998 Dec ;70(6):1022-9.

PubMed
Severity of aortic atheromatous disease diagnosed by transesophageal echocardiog...
Severity of aortic atheromatous disease diagnosed by transesophageal echocardiography predicts stroke and other outcomes associated with coronary artery surgery: a prospective study.
Anesth Analg. 1996 Oct ;83(4):701-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: