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Am J Pathol. 2013 Apr;182(4):1297-307. doi: 10.1016/j.ajpath.2012.12.035. Epub 2013 Feb 21.

Efficient amyloid A clearance in the absence of immunoglobulins and complement factors.

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  • 1Institute of Neuropathology, University Hospital of Zurich, 8091 Zurich, Switzerland. jana.sponarova@gmail.com


Amyloid A amyloidosis is a protein misfolding disease characterized by deposition of extracellular aggregates derived from the acute-phase reactant serum amyloid A protein. If untreated, amyloid A amyloidosis leads to irreversible damage of various organs, including the kidneys, liver, and heart. Amyloid A deposits regress upon reduction of serum amyloid A concentration, indicating that the amyloid can be efficiently cleared by natural mechanisms. Clearance was proposed to be mediated by humoral immune responses to amyloid. Here, we report that amyloid clearance in mice lacking complement factors 3 and 4 (C3C4(-/-)) was equally efficient as in wild-type mice (C57BL/6), and was only slightly delayed in agammaglobulinemic mice (J(H-/-)). Hence, antibodies or complement factors are not necessary for natural amyloid clearance, implying the existence of alternative physiological pathways for amyloid removal.

Copyright © 2013 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

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