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Bioorg Med Chem Lett. 2013 Apr 1;23(7):2172-6. doi: 10.1016/j.bmcl.2013.01.108. Epub 2013 Feb 1.

N-Alkyldeoxynojirimycin derivatives with novel terminal tertiary amide substitution for treatment of bovine viral diarrhea virus (BVDV), Dengue, and Tacaribe virus infections.

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  • 1Institute for Hepatitis and Virus Research, 3805 Old Easton Road, Doylestown, PA 18902, USA. yanming.du@ihvr.org

Abstract

Novel N-alkyldeoxynojirimycins (NADNJs) with two hydrophobic groups attached to a nitrogen linker on the alkyl chain were designed. A novel NADNJ containing a terminal tertiary carboxamide moiety was discovered that was a potent inhibitor against BVDV. Further optimization resulted in a structurally more stable lead compound 24 with a submicromolar EC50 against BVDV, Dengue, and Tacaribe; and low cytotoxicity.

Copyright © 2013 Elsevier Ltd. All rights reserved.

[PubMed - indexed for MEDLINE]
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