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Leuk Res. 2013 May;37(5):541-6. doi: 10.1016/j.leukres.2013.01.019. Epub 2013 Feb 28.

IL10 inversely correlates with the percentage of CD8⁺ cells in MDS patients.

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  • 1Haematology and Hemotherapy Center-University of Campinas/Hemocentro-Unicamp, Instituto Nacional de Ciência e Tecnologia do Sangue, Campinas, São Paulo, Brazil.

Abstract

The role of the immune system in myelodysplastic syndrome (MDS) progression has been widely accepted, although mechanisms underlying this immune dysfunction are not clear. CD4(+) and CD8(+) lymphocyte profiles in the peripheral blood of MDS patients were evaluated and correlated with clinical characteristics, the expression of FOXP3 and the anti-inflammatory cytokines IL10, TGFβ1 and CTLA4. IL10 expression inversely correlated with the percentage of CD8(+) cells and was higher in high-risk MDS. Our findings provide further evidence for the role of T cell-mediated IL10 production in MDS and strengthen the idea of distinct cytokine profiles in low and high-risk MDS.

Copyright © 2013 Elsevier Ltd. All rights reserved.

PMID:
23453286
[PubMed - indexed for MEDLINE]
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