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Curr Opin Cell Biol. 2013 Apr;25(2):265-71. doi: 10.1016/j.ceb.2013.01.006. Epub 2013 Feb 26.

Endodermal stem cell populations derived from pluripotent stem cells.

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  • 1Center for Cellular and Molecular Therapeutics, and Department of Pathology & Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Abstract

The generation of functional endodermal lineages, such as hepatocytes and pancreatic endocrine cells, from pluripotent stem cells (PSCs) remains a challenge. One strategy to enhance the purity, yield and maturity of endodermal derivatives is to expand endoderm committed stem or progenitor cell populations derived from PSCs before final differentiation. Recent studies have shown that this is in fact a viable option both for expanding pure populations of endodermal cells as well as for generating more mature derivative tissues, as highlighted in the case of pancreatic beta cells.

Copyright © 2013 Elsevier Ltd. All rights reserved.

PMID:
23452824
[PubMed - indexed for MEDLINE]
PMCID:
PMC3965292
Free PMC Article
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