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Indian J Hematol Blood Transfus. 2012 Mar;28(1):47-9. doi: 10.1007/s12288-011-0090-2. Epub 2011 Jul 12.

Transient leukaemia: leukaemia or leukaemoid? A diagnostic dilemma.

Author information

  • 1Department of Pathology, Pt. B.D. Sharma PGIMS, 2452, Sector-1, HUDA, Rohtak, 124001 India.

Abstract

We report a case of a newborn male who had mongoloid slant and was hypotonic at birth. Routine investigations revealed leucocytosis (WBC > 70,000/cmm) with 50% blasts in peripheral blood film. Marrow examination confirmed the excess of blasts. Karyotyping revealed 47, XY + 21 chromosomes. Due to absence of clinical symptoms, the baby was kept on follow-up without treatment. Within 7 weeks, PBF and bone marrow findings returned to normal, and the child was diagnosed as having Transient leukaemia with Down syndrome.

KEYWORDS:

Down syndrome; Transient leukaemia; Transient myeloproliferative disorder

PMID:
23450144
[PubMed]
PMCID:
PMC3311962
Free PMC Article
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