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J Pediatr Psychol. 2013 Jul;38(6):649-63. doi: 10.1093/jpepsy/jss175. Epub 2013 Feb 28.

Clinical effectiveness of comprehensive psychological intervention for nonadherence to medical treatment: a case series.

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  • 1Division of Behavioral Medicine and Clinical Psychology, Center for Promotion of Adherence and Self-Management, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA. sandra.cortina@cchmc.org



To evaluate the effectiveness of an adherence promotion intervention provided to patients and families referred to a clinical service.


6 patients and their caregivers representing 5 different chronic conditions were seen for comprehensive psychological intervention that was evaluated based on electronic monitoring of adherence to prescribed oral medication.


Time series analysis (Auto-Regressive Integrated Moving Average) indicated that for each of the 6 cases, treatment adherence increased during the intervention phase relative to nonintervention periods, but for 5 of these 6 patients, adherence decreased during the follow-up period (p < .05).


Comprehensive adherence promotion strategies delivered in standard clinical practice were effective, but the effects did not persist after treatment. Future adherence promotion interventions should focus on sustaining intervention effects.


adherence; chronic illness; clinical significance; intervention outcome

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