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Eur J Pediatr Surg. 2014 Apr;24(2):174-8. doi: 10.1055/s-0033-1333634. Epub 2013 Feb 26.

Surgical stress after open and transumbilical laparoscopic-assisted appendectomy in children.

Author information

  • 1Unit of Pediatric Surgery, Department of Pediatrics, Gynecological, Mycrobiological, and Biomedical Sciences, University of Messina, Messina, Italy.
  • 2Unit of Genetic and Pediatric Immunology, Department of Pediatric, Gynecological, Mycrobiological, and Biomedical Sciences, University of Messina, Messina, Italy.
  • 3Unit of Anesthesiology, University of Messina, Messina, Italy.
  • 4Unit of Pediatric Surgery, University of Bologna, Bologna, Italy.

Abstract

INTRODUCTION:

The transumbilical laparoscopic-assisted appendectomy (TULAA) effects on the surgical stress response in children have not been studied. Our aim is to investigate the stress response in TULAA.

METHODS:

A total of 35 children underwent the appendectomy by open approach (OA) or TULAA approach. Interleukins (ILs)-6, -18, and -10 were measured before (T0), at the beginning (T1a), and at the end of surgery (T1b) and 24 hours after (T2).

RESULTS:

An increase in IL-6 levels at T1b and T2 and in IL-18 at T2 was observed after OA. A significant increase of both IL-6 and IL-18 were observed at T2 but values were less compared with OA (11.6 ± 4.4 vs. 31.9 ± 8.9 pg/mL for IL-6, p = 0.0006; 145.6 vs. 174.9 pg/mL for IL-18, p = NS).

CONCLUSIONS:

A significant reduction in the postoperative cytokines in TULAA group suggests that this approach causes less surgical trauma in children.

Georg Thieme Verlag KG Stuttgart · New York.

PMID:
23444071
[PubMed - in process]
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