Randomized, double-blind trial of cefonicid and nafcillin in the treatment of skin and skin structure infections

J S Daly; M G Worthington; R J Andrews; R B Brown; R Schwartz; D J Sexton

doi:10.1128/AAC.34.4.654

Randomized, double-blind trial of cefonicid and nafcillin in the treatment of skin and skin structure infections

Antimicrob Agents Chemother. 1990 Apr;34(4):654-6. doi: 10.1128/AAC.34.4.654.

Authors

J S Daly¹, M G Worthington, R J Andrews, R B Brown, R Schwartz, D J Sexton

Affiliation

¹ Department of Medicine, St. Elizabeth's Hospital, Brighton, Massachusetts 02135.

Abstract

We compared treatment with one daily intravenous dose of cefonicid and multidose nafcillin in 65 patients with severe infections of the skin or skin structure. Clinical cure or improvement was achieved in 91% of the patients given cefonicid and in 87% of the patients given nafcillin (P = 0.97). The use of cefonicid may allow outpatient therapy of some severe infections.

Publication types

Clinical Trial
Comparative Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Cefonicid / administration & dosage
Cefonicid / therapeutic use*
Double-Blind Method
Drug Administration Schedule
Drug Evaluation
Female
Humans
Infusions, Intravenous
Male
Middle Aged
Nafcillin / administration & dosage
Nafcillin / therapeutic use*
Random Allocation
Skin Diseases, Infectious / drug therapy*
Skin Diseases, Infectious / physiopathology

Substances

Nafcillin
Cefonicid