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Tremor Other Hyperkinet Mov (N Y). 2011;1. pii: tre-01-32-96-3. doi: 10.7916/D82806BC. Epub 2011 Dec 12.

Further Evidence for Celiac Disease-associated Chorea.

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  • 1Departments of Neurology, James J. Peters Veterans Affairs Medical Center, Bronx, New York ; Mount Sinai School of Medicine, New York, United States of America.

Abstract

BACKGROUND:

A number of neurological conditions have been reported to be associated with gluten sensitivity, including ataxia, peripheral neuropathy, epilepsy, and occasionally, chorea. The pathogenic role of anti-gliadin antibodies has been questioned, and pathophysiology remains controversial.

CASE REPORT:

I report chorea in a patient with celiac disease, which responded to a gluten-restricted diet. The response of the movement disorder to change in diet strongly suggests a functional role for anti-gliadin antibodies in the generation of chorea, probably involving basal ganglia targets.

DISCUSSION:

Gluten sensitivity may be a treatable cause of chorea.

KEYWORDS:

Chorea; anti-gliadin antibodies; celiac disease; gluten sensitivity

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