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Mol Cell. 2013 Feb 21;49(4):601-4. doi: 10.1016/j.molcel.2013.01.030.

The "Observer Effect" in genome-wide surveys of protein-RNA interactions.

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  • 1Department of Chemistry, Rollins College, Winter Park, FL 32789, USA.

Abstract

Recent technological advances have spurred genome-wide studies that afford insights into ribonucleoprotein biology and transcript regulation on an unprecedented scale. Here we review techniques currently used to obtain genome-wide profiles of RNA-protein interactions in living cells. We highlight recent studies of the mRNA-bound proteome and address pitfalls inherent in such investigations.

Copyright © 2013 Elsevier Inc. All rights reserved.

PMID:
23438856
[PubMed - indexed for MEDLINE]
PMCID:
PMC3719848
Free PMC Article

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