The course of depression over 1 week in patients admitted to hospital following an attempted suicide was examined utilizing a clinical interview, the Zung Self-Rating Depression Scale, the Levine-Pilowsky Depression (LPD) Questionnaire and the Hamilton Rating Scale for Depression. On all measures the group had depression of moderate to marked severity at the time of attempted suicide. In males there was a statistically and clinically significant reduction in severity of depression over 1 week. This trend was also observed in the younger patients. There was no significant change in the frequency of the LPD category endogenous depression, but examination of changes in DSM-III diagnostic frequencies revealed a significant reduction in major affective disorder over 1 week. Symptom changes were also examined. Factors that may have contributed to the observed changes in depression are discussed. Therapeutic implications and further research directions are outlined.