Abstract
Macelignan found in the nutmeg mace of Myristica fragrans obtains increasing attention as a new avenue in treating various diseases. Macelignan has been shown to possess a spectrum of pharmacological activities, including anti-bacterial, anti-inflammatory, anti-cancer, anti-diabetes, and hepatoprotective activities; recently, it has also been shown to have neuroprotective activities. This review summarizes the current research on the biological effects of macelignan derived from M. fragrans, with emphasis on the importance in understanding and treating complex diseases such as cancer and Alzheimer's disease.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology
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Antioxidants / chemistry
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Antioxidants / pharmacology
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Cell Survival / drug effects
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Cell Survival / physiology
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Humans
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Lignans / chemistry*
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Lignans / pharmacology*
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Myristica*
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Neuroprotective Agents / chemistry
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Neuroprotective Agents / pharmacology
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Plant Extracts / chemistry*
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Plant Extracts / pharmacology*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Antineoplastic Agents, Phytogenic
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Antioxidants
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Lignans
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Neuroprotective Agents
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Plant Extracts
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macelignan