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Eur J Cardiothorac Surg. 2013 Sep;44(3):539-43; discussion 543. doi: 10.1093/ejcts/ezt076. Epub 2013 Feb 22.

Preoperative serum pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen level predicts postoperative distant metastasis in patients with non-small-cell lung cancer.

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  • 1Department of Thoracic and Cardiovascular Surgery, Wakayama Medical University, Wakayama, Japan. dingo_love524@yahoo.co.jp

Abstract

OBJECTIVES:

To examine the relationship between preoperative serum pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen (I-CTP) levels and postoperative distant metastasis in patients with non-small-cell lung cancer (NSCLC).

METHODS:

We retrospectively reviewed 143 patients in whom preoperative serum I-CTP level was measured from January 2006 to March 2011, including 91 males and 52 females with an average age of 70.1 ± 8.2 years. Histological subtypes included adenocarcinoma (n = 95), squamous cell carcinoma (n = 34) and other (n = 14). Preoperative serum carcinoembryonic antigen (CEA) and cytokeratin-19 fragment (CYFRA) levels were also measured. Patients with abnormal renal function or preoperative bone fractures were excluded.

RESULTS:

The mean preoperative serum I-CTP level was 4.1 ± 1.6 ng/ml, and the preoperative serum I-CTP level was elevated (>4.5 ng/ml) in 29 patients. Distant metastasis was detected in 21 patients during the 39 ± 18 (range 1-79) months of follow-up. The rate of distant metastasis was significantly higher in patients with elevated preoperative serum I-CTP levels than those with normal preoperative I-CTP levels (≤4.5 ng/ml) (P < 0.0001). The 5-year recurrence-free survival rate was lower in patients with elevated preoperative serum I-CTP levels than those with normal preoperative I-CTP levels (41.8 vs 92.9%; P < 0.0001).

CONCLUSIONS:

An elevated preoperative serum I-CTP level predicts postoperative distant metastasis in patients with NSCLC.

KEYWORDS:

Non-small-cell lung cancer; Postoperative distant metastasis; Pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen

PMID:
23435520
[PubMed - indexed for MEDLINE]
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