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Elife. 2013 Feb 19;2:e00573. doi: 10.7554/eLife.00573.

Direct detection pays off for electron cryo-microscopy.

Author information

  • is at the Department of Biochemistry and the Howard Hughes Medical Institute, Brandeis University , Waltham , Untied States niko@brandeis.edu.

Abstract

Improved electron detectors and image-processing techniques will allow the structures of macromolecules to be determined from tens of thousands of single-particle cryo-EM images, rather than the hundreds of thousands needed previously.

KEYWORDS:

Bayesian; Direct electron detectors; Electron microscopy; Image processing; S. cerevisiae; T. thermophilus; ribosome

PMID:
23426864
[PubMed]
PMCID:
PMC3576708
Free PMC Article

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