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Cancer Immunol Immunother. 2013 Mar;62(3):405-10. doi: 10.1007/s00262-012-1390-6. Epub 2013 Feb 20.

Novel mechanism of synergistic effects of conventional chemotherapy and immune therapy of cancer.

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  • 1H. Lee Moffitt Cancer Center and Research Institute, MRC 2067, 12902 Magnolia Dr., Tampa, FL 33612, USA.


There is mounting evidence to support the use of a combination of immunotherapy with chemotherapy in the treatment of various types of cancers. However, the mechanism(s), by which these modalities are synergized, are not fully understood. In this review, we discuss several possible mechanisms of the combined effect of immunotherapy and chemotherapy of cancer. We will examine various aspects of this issue such as the combination of different treatment options, the dosage for each arm of treatment, and, more importantly, the timing and sequence of the administration of these treatments.

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