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Chem Commun (Camb). 2013 Mar 28;49(25):2545-7. doi: 10.1039/c3cc38100e.

X-ray triggered release of doxorubicin from nanoparticle drug carriers for cancer therapy.

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  • 1Department of Chemistry, University of California, One Shields Ave., Davis, CA 95616, USA.

Abstract

Enhanced cellular toxicity was observed using X-ray irradiated nanoparticle drug carriers (NDC) consisting of doxorubicin (DOX) conjugated to DNA strands attached to the surface of gold nanoparticles. Kinetic studies showed that X-rays, acting as a triggering modality, generated reactive oxygen species to break DNA strands and release DOX.

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