Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Org Chem. 2013 Apr 5;78(7):3464-9. doi: 10.1021/jo400099x. Epub 2013 Feb 27.

Synthesis of 4-vinylindoles using ruthenium-catalyzed ring-closing enyne metathesis.

Author information

  • 1Department of Chemistry, Graduate School of Science, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

Abstract

The selective synthesis of substituted 4-vinylindoles by the ring-closing enyne metathesis (RCEM)/dehydration sequence is reported. In contrast with many known methods in which a pyrrole ring is constructed onto a functionalized benzene precursor, this method enables the construction of a benzene ring onto a pyrrole precursor. The RCEM/tautomerization sequence for the synthesis of 7-hydroxy-4-vinylindole is also presented as an application of this method.

PMID:
23421372
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Chemical Society
    Loading ...
    Write to the Help Desk