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Histol Histopathol. 2013 May;28(5):655-61. Epub 2013 Feb 19.

The level of phosphorylated Akt predominantly reflects the expressive status of CerbB2 in invasive breast cancer.

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  • 1Department of Pathology, Health Science Center of Peking University, Beijing, China.


Although some evidence has been documented on EGFR/PI3K mediation of Akt activation in breast cancers, ILK and DNA-PK have not been investigated so far. The aim of this study was to analyze the expression of phosphorylated Akt (pAkt) in breast cancer, with respect to its upstream regulators. The immunostaining of pAkt (Ser473) in 70 invasive breast cancers revealed that status of CerbB2 could play a major role in Akt phosphorylation, while ILK was also involved in the stimulated level of pAkt. The results would provide an important clue for the activation of Akt and potential targeted therapy in breast cancer.

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