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J Asian Nat Prod Res. 2013;15(3):315-8. doi: 10.1080/10286020.2012.762641. Epub 2013 Feb 18.

A new antibacterial denitroaristolochic acid from the tubers of Stephania succifera.

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  • 1National Center of Important Tropical Crops Engineering and Technology Research, Chinese Academy of Tropical Agricultural Sciences, Haikou 57110 , China.


A new denitroaristolochic acid, demethylaristofolin C (1), together with six known alkaloids, crebanine N-oxide (2), (-)-sukhodianine-β-N-oxide (3), palmatine (4), corydalmine (5), dehydrocorydalmine (6), and corynoxidine (7), was isolated from the tubers of Stephania succifera. The structure of demethylaristofolin C was elucidated by spectroscopic techniques (UV, IR, 1D, and 2D NMR) and HR-ESI-MS analyses. These compounds exhibited antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains in different degrees.

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