Send to:

Choose Destination
See comment in PubMed Commons below
Spectrochim Acta A Mol Biomol Spectrosc. 2013 Apr 15;107:24-30. doi: 10.1016/j.saa.2013.01.014. Epub 2013 Jan 23.

Determination of 6-thioguanine based on localized surface plasmon resonance of gold nanoparticle.

Author information

  • 1School of Physical and Chemical, Henan Polytechnic University, Jiaozuo 454000, PR China.


Gold nanoparticles exhibit the optical properties of localized surface plamon resonance (LSPR) and are widely applied to the biosensors. The application of gold nanoparticles to the determination of anticancer drug 6-thioguanine (6-TG) was discussed. The binding of 6-TG molecule to the surface of gold nanoparticles alters the local refractive index in the vicinity of the nanoparticles and results in a shift of the LSPR spectrum. The experimental conditions were examined and optimized. Under the optimal conditions, the ratios of absorbances at two wavelengths are directly proportional to the concentrations of 6-TG. The developed method is simple, rapid, and sensitive. In addition, this method is particularly attractive because organic cosolvents, light-sensitive dyes, and sophisticated instruments are not required. This method was successfully applied to the determination of 6-TG in real samples and the results were satisfactory.

Copyright © 2013 Elsevier B.V. All rights reserved.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk