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Immunity. 2013 Feb 21;38(2):349-59. doi: 10.1016/j.immuni.2012.10.019. Epub 2013 Feb 15.

Mast cell interleukin-10 drives localized tolerance in chronic bladder infection.

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  • 1Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.

Abstract

The lower urinary tract's virtually inevitable exposure to external microbial pathogens warrants efficient tissue-specialized defenses to maintain sterility. The observation that the bladder can become chronically infected in combination with clinical observations that antibody responses after bladder infections are not detectable suggest defects in the formation of adaptive immunity and immunological memory. We have identified a broadly immunosuppressive transcriptional program specific to the bladder, but not the kidney, during infection of the urinary tract that is dependent on tissue-resident mast cells (MCs). This involves localized production of interleukin-10 and results in suppressed humoral and cell-mediated responses and bacterial persistence. Therefore, in addition to the previously described role of MCs orchestrating the early innate immunity during bladder infection, they subsequently play a tissue-specific immunosuppressive role. These findings may explain the prevalent recurrence of bladder infections and suggest the bladder as a site exhibiting an intrinsic degree of MC-maintained immune privilege.

Copyright © 2013 Elsevier Inc. All rights reserved.

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PMID:
23415912
[PubMed - indexed for MEDLINE]
PMCID:
PMC3647685
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