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Transfus Apher Sci. 2013 Apr;48(2):273-5. doi: 10.1016/j.transci.2013.01.008. Epub 2013 Feb 13.

Resistant oral mucosal lesions in pemphigus vulgaris responsive to double filtration plasmapheresis: First case report from Turkey.

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  • 1Adnan Menderes University, Department of Dermatology, Turkey. esavk@adu.edu.tr

Abstract

BACKGROUND:

Adjuvant therapeutic methods are employed when pemphigus vulgaris (PV) fails to be controlled by conventional corticosteroid treatment.

OBJECTIVE:

The efficacy of double filtration plasmapheresis (DFPP) was investigated in a PV patient with severe, refractory mucosal disease.

METHODS:

A total of 3 DFPP cycles, each cycle consisting of 5 double filtration sessions conducted on alternate days was completed.

RESULTS:

DFPP provided immediate clinical relief of symptoms as well as a significant decrease in anti-desmoglein antibody levels and allowed for a much lower corticosteroid dose.

CONCLUSION:

DFPP was an effective and safe adjuvant therapy in our patient with PV and it offers a valid treatment option in PV patients with recalcitrant disease.

Copyright © 2013 Elsevier Ltd. All rights reserved.

[PubMed - indexed for MEDLINE]
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