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Cell. 2013 Feb 14;152(4):671-2. doi: 10.1016/j.cell.2013.01.050.

A cool way to live long.

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  • 1The Scripps Research Institute, Department of Chemical Physiology, La Jolla, CA 92037, USA. bconti@scripps.edu


In this issue, Xiao et al. challenge the notion that cold temperatures promote longevity solely through thermodynamic effects. They show that low temperatures activate a cold-sensitive cation channel, TRPA-1, which triggers a complex signaling pathway in both neurons and nonneuronal cells to extend the lifespan of Caenorhabditis elegans.

Copyright © 2013 Elsevier Inc. All rights reserved.

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