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Diagn Microbiol Infect Dis. 2013 Jun;76(2):239-40. doi: 10.1016/j.diagmicrobio.2013.01.002. Epub 2013 Feb 13.

Comprehensive update of dalbavancin activity when tested against uncommonly isolated streptococci, Corynebacterium spp., Listeria monocytogenes, and Micrococcus spp. (1357 strains).

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  • 1JMI Laboratories, North Liberty, IA, USA. Electronic address: ronald-jones@jmilabs.com.

Erratum in

  • Diagn Microbiol Infect Dis. 2013 Jul;76(3):401.

Abstract

Dalbavancin is an investigational lipoglycopeptide having an extended serum elimination half-life allowing once-weekly dosing. Data from testing 1357 strains of uncommonly isolated species expand the dalbavancin spectrum details as follows (MIC50/90): β-haemolytic streptococcal serogroups C, F, and G (≤0.03/≤0.03 μg/mL), 7 viridans group of streptococci (≤0.03/≤0.03-0.06 μg/mL), 5 Corynebacterium spp. (0.06/0.12 μg/mL), Listeria monocytogenes (0.06/0.12 μg/mL), and Micrococcus spp. (≤0.03/≤0.03 μg/mL). Among all reported isolates, 99.8% of tested strains were inhibited at dalbavancin MIC values at ≤0.12 μg/mL. Dalbavancin remains very potent against rarer Gram-positive pathogens, using in vitro test experience with organisms cultured through 2011.

Copyright © 2013 Elsevier Inc. All rights reserved.

PMID:
23414746
[PubMed - indexed for MEDLINE]
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